Science Highlights
Published on August 03, 2026
NF-κB Signaling and Response Durability After Ide-Cel
by Blood
Noble JD, Peixoto BC, Menges MA, et al. Product-Intrinsic NF-κB-Driven Transcriptional Programs Connote Durability of CAR-T Response in Multiple Myeloma. Blood. 2026; (doi: 10.1182/blood.2025031843).
Single-cell RNA sequencing of 40 idecabtagene vicleucel (ide-cel) products sheds light on the role that NF-κB signaling plays in the durability of response to chimeric antigen receptor (CAR) T-cell treatment for multiple myeloma. The analyses showed that CD4 CAR-T cells generating durable responses shared a common characteristic: a transcriptional program marked by high levels of NF-κB activity, which in turn was associated with longer progression-free survival and overall survival. Identifying drivers of durable response is important for informing patient counseling and for optimizing CAR-T efficacy. There are additional implications for CAR-T manufacturing decisions, as researchers also determined that elevated NF-κB activity is a global marker of T-cell fitness that is present before CAR-T cells are even engineered.
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