Healio Blog
Published on October 22, 2026
Healio Blog: Advancing Acute GVHD Care: Inside ASTCT’s Updated Clinical Practice Recommendations
by ASTCT Staff
Acute graft-versus-host disease remains one of the most challenging complications of allogeneic hematopoietic cell transplantation.
Although advances in GVHD prevention have reduced rates of severe disease, significant questions remain regarding diagnosis, grading, risk stratification and treatment selection.
To address these challenges, the American Society for Transplantation and Cellular Therapy (ASTCT) recently published updated clinical practice recommendations in Transplantation and Cellular Therapy. The guidance, titled “Clinical management of acute graft-versus-host disease: An evidence-based review from the ASTCT Committee on Practice Guidelines,” provides the first comprehensive update on the topic in nearly 15 years.
In this Q&A, Zachariah DeFilipp, MD, director of the bone marrow transplant program at Mass General Brigham Cancer Institute and associate professor of medicine at Harvard Medical School, discusses the key recommendations, the evolving role of biomarkers and what the future may hold for acute GVHD management.
Read the full article on Healio.
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