Science Highlights
Published on January 13, 2026
Donor selection strategies in PTCy haploidentical transplantation
by Bone Marrow Transplantation
Sanz J, Ferhat A-T, Raiola AM, et al. Donor Selection in PTCy Haploidentical Transplant for Acute Lymphoblastic Leukemia: A Study From the ALWP of the EBMT. Bone Marrow Transplantation. 2025; (doi: 10.1038/s41409-025-02763-3).
Donor traits and graft sources have a role in how outcomes play out after haploidentical hematopoietic cell transplantation (HCT) for acute lymphoblastic leukemia (ALL), report members of a working group within the European Society for Bone Marrow Transplantation. Their retrospective analysis included a sample population of 933 ALL patients who received post-transplant cyclophosphamide-based prophylaxis against graft-versus-host disease (GVHD). The data pointed to an elevated risk for chronic GVHD when older donors were enlisted and when male recipients were paired with female donors. Additional findings favored bone marrow grafts over peripheral blood grafts, which were used 69% of the time but correlated to inferior overall survival (OS) and GVHD-free/relapse-free survival. Investigators noted improved OS and reduced non-relapse mortality in HCT with cytomegalovirus (CMV)-seronegative donors and recipients, underscoring the importance of this kind of matching for CMV-seronegative recipients.
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