GVHD
Published on February 20, 2024
CSF1R antibody blockade studied to prevent CNS cGVHD in mice
by Blood
Adams RC, Carter-Cusack D, Llanes GT, et al. CSF1R Inhibition Promotes Neuroinflammation and Behavioral Deficits During Graft-Versus-Host Disease in Mice. Blood. 2023; (doi: 10.1182/blood.2023022040).
Antibody-driven suppression of colony-stimulating factor 1 receptor (CSF1R) is not a viable defense against chronic graft-versus-host disease (GVHD) of the central nervous system (CNS), scientists report. They had been encouraged by the results of previous research, where this approach showed strong potential for depleting brain-infiltrating donor MHC class II+ bone marrow-derived macrophages implicated in CNS GVHD. However, during acute or chronic CNS GVHD, which can occur following allogeneic hematopoietic stem cell transplantation, the team found that CSF1R inhibition actually promoted neuroinflammation and behavioral deficits. In light of the neurological toxicity in this setting, IFNGR signaling is a more promising target for combating chronic GVHD of the CNS. Clinical studies of CSF1R blockade already in progress must also examine neurological safety signals in patients, the researchers advise.
Read More
![]()