by Nature Medicine
Additional study of mivocabtagene-autoleucel (miv-cel) is warranted for the treatment of rheumatoid arthritis (RA) based on evidence demonstrating acceptable tolerability in the short term,...
by Transplantation and Cellular Therapy
Researchers behind a first-in-human clinical study say their work supports the use of adoptive regulatory T cells (Treg) to combat graft-versus-host disease (GVHD) following allogeneic...
by Blood
Notch1 is known for its role in upregulating pro-inflammatory and survival genes in normal T cells, but research suggests the receptor also plays an important part in chimeric antigen receptor...
by Clinical & Translational Immunology
Scientists have identified a method to minimize waste when manufacturing chimeric antigen receptor (CAR) T cells and improve their efficacy by harnessing the power of natural killer (NK) cells.
by Molecular Therapy Advances
Scientists believe lentiviral (LV)-based virus-like particles (VLPs) could improve chimeric antigen receptor (CAR) T-cell therapies and enable rapid, scalable production of gene-edited CAR T-cells...
by Blood
Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 and CD70 has the potential to improve outcomes in individuals with follicular lymphoma (FL) who have elevated relapse risk.