Preclinical evidence warrants further testing of P2X7 blockades as a preventative therapy against graft-versus-host disease (GVHD), a complication of allogeneic hematopoietic stem cell...
IFNγ blockade curtails the incidence of high-grade toxicities associated with chimeric antigen receptor (CAR) T-cell therapy, researchers report. Observations from a murine model of toxicities...
Findings from a real-world study affirm belumosudil as a promising option for patients with chronic graft-versus-host disease and inadequate response to at least two prior lines of therapy. The...
Contrary to conventional practice recommending against upfront hematopoietic cell transplantation (HCT) for severe aplastic anemia (SSA), except in the case of young recipients with matched...
by Blood Advances
An innovative high-throughput platform that allows important T cell receptors (TCRs) to be cloned at a rapid pace could help scientists better understand the mechanics of minor histocompatibility...
by Blood
Owing to its consistent presence in B-cell lymphomas and leukemias, researchers tout CD22's promise as a therapeutic target, but they suspect chimeric antigen receptor (CAR) immunotherapy may...