BASIC AND
TRANSLATIONAL
SCIENTIFIC MEETING

Mechanisms of Tolerance
Session Chair: Fadi Lakkis, MD; Stanford University

• Innate Allorecognition as a Barrier to Tolerance – Fadi Lakkis, MD; Stanford University
• Glycan regulation of fetomaternal tolerance – Adrian Erlebacher, MD, PhD; University of California, San Francisco
• Tolerizing dendritic cells that program peripheral Tregs – Rabi Upadhyay, MD; NYU School of Medicine
• Oral Abstract: Adrenergic activation induces acute thymic involution – Kimon Argyropoulos, MD, PhD; Memorial Sloan Kettering Cancer Center

Myeloid Cells in Immunotherapy Outcomes
Session Chair: Florent Ginhoux, PhD; Institut Gustave Roussy

• Embracing Tumor Macrophage Heterogeneity – Florent Ginhoux, PhD; Institut Gustave-Roussy
• Neutrophils: The Power of Many – Lai Guan Ng, PhD; Westlake University
• Reprogramming T Cell Therapies – Laurie Menger, PhD; Institut Gustave-Roussy
• Oral Abstract: Rebuilding the Immune System: A Single Cell Map of Immune Reconstitution Across GvHD Prophylaxis Strategies from BMT CTN 1301 - Rachel Lorenc, MD, PhD Student; Memorial Sloan Kettering Cancer Center; Maxim Maron, MD, PhD; Memorial Sloan Kettering Cancer Center

Stem Cell Biology
Session Chair: Alan Hanash, MD, PhD; Memorial Sloan Kettering Cancer Center

• Tissue Stem Cells: The Benefits and Downsides of a Lifetime of Stressful Encounters – Elaine Fuchs, PhD; Rockefeller University
• Immune-Mediated Regulation of the Intestinal Stem Cell Compartment After Bone Marrow Transplantation – Alan Hanash, MD, PhD; Memorial Sloan Kettering Cancer Center
• Cell-nonautonomous control of epithelial stem cell propertoes - Ramesh A. Shivdasani, MD, PhD; Dana-Farber Cancer Institute
• Oral Abstract: Microbial Regulation of Hematopoietic Recovery After Hematopoietic Stem Cell Transplant - Belinda Valerie Candra, PhD; Baylor College of Medicine

CAR T-Cells and Genome Manipulation
Session Chair: Pietro Genovese, PhD; Dana-Farber Cancer Center

• Redesigning Surface Antigens for Next-Generation Hematopoietic Gene Therapy – Pietro Genovese, PhD; Dana-Farber Cancer Center
• Targeted LNP Delivery of an RNA Gene Writer In Vivo Enables Generation of Functional CAR-T Cells – Cecilia Cotta-Ramusino, PhD; Tessera Therapeutics
• Genome Editing to Enhance CAR T-Cell Potency and Safety: The CD5 Knockout Paradigm – Marco Ruella, MD; University of  Pennsylvania
• Oral Abstract: CAR T-KLR Cell Therapy Demonstrates More Durable and Safe Control of Malignancies - Kazim Panjwani, PhD; Memorial Sloan Kettering Cancer Center

Keynote Dinner
Gene Therapy for Sickle Cell Disease: Where do we stand in the treatment for all?

Marina Cavazzana, MD, PhD; Imagine Institute 

Tumor Immunology
Session Chair: Catherine Wu, MD; Dana-Farber Cancer Center

• New Tools for Probling the GvL and GvHD Landscape – Catherine Wu, MD, PhD; Dana-Farber Cancer Institute
• Genomic Tools for Measuring Biology in Space and Time – Fei Chen, PhD; Broad Institute
• Molecular tools to decode MRD progression - Pavan Bachireddy, MD; MD Anderson Cancer Center
• Oral Abstract: Detection of novel T-cell receptor: minor histocompatibility antigen interactions in mouse models of graft-vs-host disease - Kevin Quann, MD, PhD; University of Pittsburgh

Humoral Immunity
Mark Shlomchik, MD; University of Pittsburgh  

• The Diversity of B Cell Immune Responses – Mark Shlomchik, MD; University of Pittsburgh 
• Clonal Dynamics of the Antibody Response – Gabriel Victora, PhD; Rockefeller University
• Understanding the Biology of Human Plasma Cells – F. Eun-Hyung Lee; Emory University
• Oral Abstract: Epitranscriptomic Modification Sensing by LRPPRC Defines a Novel Regulatory Axis to Enhance Adoptive Cell Therapy - Jeremy Meier, MD, PhD; University of North Carolina 

A Supply Side Approach to Enhancing Thymus Regeneration
David Scadden, MD; Harvard Stem Cell Institute